Knee replacement linked to weight gain: study

Knee replacement linked to weight gain: study 

NEW YORK: Being overweight is known to increase the risk of needing a knee replacement, but a new study finds that knee replacement surgery may also raise a person's risk of gaining weight, according to a US study.
Researchers, whose findings appeared in the journal Arthritis Care & Research, analyzed the medical records of nearly 1,000 knee-replacement surgery patients, and found that 30 percent of them gained five percent or more of their body weight in the five years following surgery.
One possible explanation for the counter-intuitive results, experts said, is that if people have spent years adapting to knee pain by taking it easy, they don't automatically change their habits when the pain is reduced.
"Patients who undergo knee arthroplasty are at increased risk of clinically important weight gain following surgery," wrote study leader Daniel Riddle, a professor at Virginia Commonwealth University.
"Future research should develop weight loss/maintenance interventions particularly for younger patients who have lost a substantial amount of weight prior to surgery, as they are most at risk for substantial post surgical weight gain."
Riddle's group used a patient registry from the Mayo Clinic in Rochester, Minnesota, which collected information on 917 knee replacement patients before and after their procedures.
The researchers found that five years after surgery, 30 percent of patients had gained at least five percent of their weight at the time of the surgery - at least 5 kg or more on a 100-kg person, for example.
In contrast, fewer than 20 percent of those in a comparison group of similar people who had not had surgery gained equivalent amounts of weight in the same period.
"After knee replacement we get them stronger and moving better, but they don't seem to take advantage of the functional gains," said Joseph Zeni, a physical therapy professor at the University of Delaware, who was not part of the study.
"I think that has to do with the fact that we don't address the behavioral modifications that have happened during the course of arthritis before the surgery."
Riddle's team explained that this degree of weight gain can lead to "meaningful effects on cardiovascular and diabetes related risk as well as pain and function."
Part of the explanation for the weight gain could be the age at which patients get surgery. People in their 50s and 60s tend to gain weight anyway. Still, in light of the lower rates of weight gain in the comparison group, which was also middle aged and older, Riddle said something else may also be at work.
Indeed, the team found that patients who had lost weight before their surgery were slightly more likely to gain weight afterwards - perhaps because when people lose weight in anticipation of an event, such as surgery, they are more likely to put it back on after they're achieved the goal.
Zeni said that to help people stave off weight gain after surgery, health care providers need to address the sedentary lifestyle people often adopt to accommodate their arthritis.

 


Vitamin D deficiency causes bone diseases

Vitamin D deficiency causes bone diseases 

ISLAMABAD: Dr Sayed Mehfooz Alam, consultant Rheumatologist said that 40 per cent people across the world suffer from bone diseases because of vitamin D deficiency.
He said that less physical activity, junk food and a busy lifestyle are the main reasons for this disease.
He said in daily routine use of computer, video games and TV has increased a lot which ends up with less physical activity causing arthritis (joints' pains).
Talking about preventive measures relating to arthritis, he suggested a balanced diet and reduction in weight.
Dr Mehfooz said that wrong posture while sitting and during sleep also promote the problems of neck and backache.
Excessive use of red meat, fish, nuts, spinach and tomato increases uric acid in human body which causes joint swelling, he added.
He recommended that one should enhance the use of dairy products like egg, milk and yogurt in their normal diet and must control cholesterol level for healthy life.

 

US doctors defeat leukemia with modified HIV

US doctors defeat leukemia with modified HIV
 
NEW YORK: US doctors say they have saved a seven-year-old girl who was close to dying from leukemia by pioneering the use of an unlikely ally: a modified form of the HIV virus.
After fighting her disease with chemotherapy for almost two years and suffering two relapses, the young girl "faced grim prospects," doctors at Children's Hospital of Philadelphia said.
So in February this year they agreed to take her on in an experimental program that fought fire with fire.
Helped by a genetically altered HIV virus -- stripped of its devastating properties that cause AIDS -- doctors turned the girl's own immune cells into a superior force able to rout the "aggressive" leukemia.
Emily Whitehead was the first child and is one of only a handful of people in total to be given what's officially known as CTL019 therapy. The hospital stressed this could not yet be called "a magic bullet."
However in her case at least the success was dramatic.
First, millions of the girl's natural immune system cells were removed. Then the modified HIV virus was used to carry in a new gene that would boost the immune cells and help them spot, then attack cancer cells that had previously been able to sneak in "under the radar," the hospital said on its website.
Finally the rebooted immune cells were sent back in to do their work.
"The researchers have created a guided missile that locks in on and kills B cells, thereby attacking B-cell leukemia," the hospital said.
Pediatric oncologist Stephan Grupp, who cared for the girl, explained Tuesday that there was never any danger of AIDS during the process.
"The way we get the new gene into the T cells (immune cells) is by using a virus. This virus was developed from the HIV virus, however all of the parts of the HIV virus that can cause disease are removed," he said in an email.
"It is impossible to catch HIV or any other infection. What's left is the property of the HIV virus that allows it to put new genes into cells."
During the treatment, Emily became very ill and went into the intensive care unit, underlining how risky the procedure can be. However, drugs that partly block the immune reaction were administered, without interfering with the anti-leukemia action, and she recovered, the hospital said.
The result was "complete" and best of all, the doctors say, the boosted immune shield continues "to remain in the patient's body to protect against a recurrence of the cancer."
"She has no leukemia in her body for any test that we can do -- even the most sensitive tests," Grupp told ABC television. "We need to see that the remission goes on for a couple of years before we think about whether she is cured or not. It is too soon to say."
Emily's parents Kari and Tom told the hospital that the success of the operation has changed their world. Instead of chemotherapy that made the girl lose all her hair, she is now back in school, walking her dog Lucy and playing soccer. "T cell therapy was really the only option left for Emily," Tom said.
Grupp said on the Children's Hospital of Philadelphia website that cell therapies might eventually replace the more costly, painful bone marrow transplant treatment, a standard last-ditch defense against cancer.
"I've been meeting with families to discuss bone marrow transplant for 20 years," he said.
"In almost every meeting, I say that bone marrow transplant is very hard and that if we had an alternative for children at that point in treatment, I would be delighted to put myself out of business. And for the first time, we're seeing how that might actually happen." (AFP)

 

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